Both Lugol's solutions are available - the standard type and the stabilized type. Suitable protocols are available on the internet or on demand. For further information about the wide range of products available from Merck Millipore for bacteriologica stainings, please contact Merck Millipore see details above. View full company details. Email Supplier. Next article » Merck Chromogenic Me Lugol's solution is an aqueous solution which contains iodine I 2 and potassium iodide KI in a ratio of Lugol's iodine solution is used for Gram staining and can be used as an antiseptic and disinfectant for emergency disinfection of drinking water, and as a reagent for starch detection in routine laboratory and other medical tests.
Product Presentation Cat. Request Information. Next article » Merck Chromogenic Media - Fast,. It is not proven if the iodine background, ethnicity or other factors make the relatively low number of patients escaping from iodide blocking in Japan a phenomenon which should not be feared to the same extent as it has in the past. To explore this investigations in areas with different iodine backgrounds have to be performed with focus on control of GD, degree of escape from therapy and adverse effects.
Adverse events need to be better recorded, both in the short and long-term use of LS therapy. The optimal dose of LS also needs to be clarified. Moreover, the mechanisms of LS, especially on the vasculature are intriguing and merit further research. It is fascinating that almost years since this compound was invented, and years since it became a treatment in GD, we still do not fully understand how the effects on the vasculature are mediated.
We also do not know if the vasculature effects in GD are present in other thyroidal diseases such as goiter or multinodular diseases, or in other vascular beds in the body. LS has been advocated for almost years in the treatment of GD.
It has effects in decreasing thyroid hormones, and possibly in reducing blood flow during thyroidectomy. LS is used both in combination with antithyroid drugs preoperatively in planned thyroidectomies in certain centers routinely, and alone as a rescue therapy if severe side effects to antithyroid drugs have occurred.
These effects, especially on the vasculature have to explored further, together with investigations on how common there is an escape from LS-blocking, the mechanisms of action, which doses that should be applied, and registration of side effects.
This article does not contain any studies with human participants or animals performed by any of the authors. National Center for Biotechnology Information , U. Published online Oct Jan Calissendorff 1, 2 and Henrik Falhammar 1, 2. Author information Article notes Copyright and License information Disclaimer.
Corresponding author. Received Aug 11; Accepted Oct This article is distributed under the terms of the Creative Commons Attribution 4. This article has been cited by other articles in PMC. Open in a separate window. Mechanisms of iodide on the thyroid gland and the escape phenomenon In the short term LS reduces the thyroid hormones, T4 and T3 by increasing iodine uptake and inhibiting the enzyme thyroid peroxidase [ 22 ], thus attenuating oxidation and organification of thyroid hormones [ 23 ].
Treatment with LS LS tastes bitter and is also corrosive, and this should be disguised by taking it with a sweet drink such as apple juice. Iodide compounds and iodine content There are several iodide compounds available. Adverse effects LS and other iodide preparations seem to have low frequency of adverse effects. Future research directions Most studies on LS therapy have been retrospective and often with few participants. Conclusion LS has been advocated for almost years in the treatment of GD.
Compliance with ethical standards Conflict of interest The authors declare that they have no competing interests. Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors. References 1. Plummer HS. The value of iodine in exopthalmic goiter. Review of oral cholecystographic agents for the management of hyperthyroidism.
Braga M, Cooper DS. Clinical review oral cholecystographic agents and the thyroid. Calissendorff J, Falhammar H. Shinall MC, Jr. Is potassium iodide solution necessary before total thyroidectomy for Graves disease? Hope N, Kelly A. Thyroid J. Incidence of hyperthyroidism in Sweden. Abraham, A.
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Iodine-Induced hypothyroidism. Woeber KA. Iodine and thyroid disease. Questions to Ask About Cancer. Choices for Care. Talking about Your Advanced Cancer. Planning for Advanced Cancer. Advanced Cancer and Caregivers. Questions to Ask about Advanced Cancer. Managing Cancer Care. Finding Health Care Services. Advance Directives.
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